Raman Fingerprints of the SARS-CoV-2 Delta Variant and Mechanisms of Its Instantaneous Inactivation by Silicon Nitride BioceramicsSARS-CoV-2 Delta 변이체의 라만 지문과 질화규소 바이오세라믹에 의한 즉각적인 비활성화 메커니즘Article Published on 2022-08-122022-09-11 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Amino acid arginine B.1.617.2 collected Delta delta variant effective environmental sanitation fingerprint fraction hydrophobic hydrophobic interaction hydrophobic interactions inactivation Inorganic compound instantaneous instantaneous virus inactivation Japanese Lineage marker mechanism methionine molecular Mutation mutations Nitride Occurrence Oxidation Particle Protein purine purines pyrimidines Raman spectroscopy reaction receptor recorded referred to residue residues RNA Safe SARS-CoV-2 secondary structure silicon silicon nitride. sulfur the SARS-CoV-2 tyrosine variant viral inactivation virion virions virus [DOI] 10.1021/acsinfecdis.2c00200 PMC 바로가기 [Article Type] Article
Widespread occurrence of covalent lysine-cysteine redox switches in proteins단백질에서 공유 라이신-시스테인 산화 환원 스위치의 광범위한 발생Article Published on 2022-04-012022-09-11 Journal: Nature chemical biology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 binding coronavirus cysteine cysteines database DNA domain effectors enzyme Gene Expression homeostasis human protein human proteins instances life lysine motif nitrogen NOS Occurrence oxygen Pathogens pathophysiological conditions physiological plant pathogens Protein protein structure Proteins Regulatory reported SARS-CoV-2 severe acute respiratory syndrome Coronavirus Signaling substrates sulfur trivalent variants whole protein [DOI] 10.1038/s41589-021-00966-5 PMC 바로가기 [Article Type] Article
Regulation of gliotoxin biosynthesis and protection in Aspergillus species아스 페르 길 루스 종에서의 글리 톡신 생합성 및 보호의 조절Research Article Published on 2022-01-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis approach aspergillosis Aspergillus Aspergillus fumigatus Aspergillus oryzae best cause colonisation component conserved disease Disease progression enzyme expresse expression expression of gene expression pattern facilitate fungal Genes genetic determinant genetic determinants Genome Glia homolog homologs human immune response identify Immune cell impair include involved kojic acid mechanism metabolism modulated mycotoxin negative regulation neutralising nidulan nidulans observé occur Occurrence pathogenicity producing regulate required responses RNA-sequencing screened secrete secretion sensitivity significantly sulfur Taking TFS toxic effect toxic effects transcription factor transcription factors transcriptional transcriptional response virulence [DOI] 10.1371/journal.pgen.1009965 PMC 바로가기 [Article Type] Research Article
Raman Molecular Fingerprints of SARS‐CoV‐2 British Variant and the Concept of Raman BarcodeSARS -COV -2 영국 변형의 라만 분자 지문 및 라만 바코드의 개념Research Article Published on 2021-12-072022-09-01 Journal: Advanced Science [Category] SARS, 변종, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity Amino acid antibody resistance barcode BOLD building Characteristics collected concept conformational coronavirus Coronavirus disease 2019 COVID‐19 detrimental diagnostic diagnostic sensitivity diagnostics facilitate fingerprint fingerprints fraction functional Host receptors hydrophobic hydrophobic interaction hydrophobic interactions information isomerism Japan Japanese molecular multiple mutation multiple mutations Mutation Nucleocapsid proteins phenol Protein purine purines pyrimidines Raman Raman spectroscopy respiratory RNA SARS‐CoV‐2 SARS‐CoV‐2 scrutiny secondary structures sensitivity severe acute respiratory syndrome Coronavirus spike and nucleocapsid proteins Spike proteins statistical sulfur Support translate tyrosine variant variants virus virus variant virus variants while [DOI] 10.1002/advs.202103287 PMC 바로가기 [Article Type] Research Article
The Se–S Bond Formation in the Covalent Inhibition Mechanism of SARS-CoV-2 Main Protease by Ebselen-like Inhibitors: A Computational Study엡셀렌 유사 억제제에 의한 SARS-CoV-2 주요 프로테아제의 공유 결합 억제 메커니즘에서 Se-S 결합 형성: 전산 연구Article Published on 2021-09-102022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 치료제, [키워드] antiviral therapies apo form bond canonical catalytic dyad Combination complex covalent bond DFT Donor drug Ebselen Formation functional H-bond His41 hydrogen hydroxyl hydroxyl group inhibition inhibition mechanism knowledge less M pro mechanism member molecular dynamics Molecular dynamics simulation performed position potential energy potential energy surface protease Protease inhibitor SARS-CoV-2 SARS-CoV-2 main protease Se–S covalent bond selective Selenium sulfur theory [DOI] 10.3390/ijms22189792 PMC 바로가기 [Article Type] Article
Food Containing Bioactive Flavonoids and Other Phenolic or Sulfur Phytochemicals With Antiviral Effect: Can We Design a Promising Diet Against COVID-19?Nutrition Published on 2021-06-172022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] activity Against alleviate anti-inflammatory action Antiviral approved Bioavailability Can complementary Containing contributing to coronavirus coronavirus disease country COVID-19 diet distribution drug flavanone flavonoid flavonol food Functional foods global pandemic Health Infectious disease information knowledge Laboratory mechanism molecular monoclonal antibodies Novel coronavirus Other pathogen Perspective phytochemical phytochemicals plant Prevent Research researcher SARS-CoV-2 Secondary Metabolite Spread sulfur Therapeutic approach therapeutic approaches therapy these compounds Vaccine viral infection viral pathology while [DOI] 10.3389/fnut.2021.661331 PMC 바로가기 [Article Type] Nutrition
Proteomic profiling of the monothiol glutaredoxin Grx3 reveals its global role in the regulation of iron dependent processes모노티올 글루타레독신 Grx3의 단백질체 프로파일링은 철 의존적 과정의 조절에서 그것의 전체적인 역할을 보여줍니다Research Article Published on 2020-06-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affinity purification amplify applied approach associations biological processes Candida albican Candida albicans Cell cellular processes cofactor commensal component conserved Critical cytosolic determine DNA essential nutrient expression function functions fungal Gene Expression genotoxic glutaredoxin growth Grxs Heat shock histidine homeostasis Host human host humans in vivo interact iron iron homeostasis leucine maintain mass spectrometry metabolism mutant organism Organisms oxidative oxygen pathogen Pathogens performed Protein protein translation proteomic regulate Regulation regulatory circuit repair repression required respond reveal sulfur Support survival Taking target gene Target genes the cell Tryptophan utilization virulence [DOI] 10.1371/journal.pgen.1008881 PMC 바로가기 [Article Type] Research Article
Exome-wide association study reveals largely distinct gene sets underlying specific resistance to dengue virus types 1 and 3 in Aedes aegypti엑솜 전체의 연관성 연구는 이집트숲모기(Aedes aegypti)에서 뎅기열 바이러스 유형 1 및 3에 대한 특이적 내성을 기본으로 하는 크게 구별되는 유전자 세트를 보여줍니다Research Article Published on 2020-05-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adjusted Aede allelic variant allelic variants association ATP average binding activity compatibility Dengue dengue virus DENV-1 DENV-3 Exome exomes exposure to Frequency Gabon Genes Genetic genetic architecture genetic marker Genetic polymorphism genetic polymorphisms Genetic variation Genome group Host host gene host genes host-pathogen interactions hosts identify indicate Infection Interaction invertebrate invertebrates investigated involved mechanism Mosquito natural population p values pathogen pathogen genotype pathogen-specific Pathogens phenotype phenotypic polymorphism Region reveal sequenced significantly single-nucleotide single-nucleotide polymorphism SNP specific resistance specificity statistical strain Strains sulfur susceptible the mosquito transmembrane variant Variation with infection Zinc zinc ion [DOI] 10.1371/journal.pgen.1008794 PMC 바로가기 [Article Type] Research Article
Are Iranian Sulfur Mustard Gas-Exposed Survivors More Vulnerable to SARS-CoV-2? Some Similarity in Their PathogenesisResponder Tools Published on 2020-05-182022-10-31 Journal: Disaster Medicine and Public Health Preparedness [Category] COVID-19, MERS, SARS, [키워드] ACE2 acute respiratory syndrome Angiotensin-converting enzyme caused coronavirus Coronavirus disease 2019 COVID-19 COVID-19 infection Cytokine storm dysregulation entry receptor functional Health immune system Infectious disease Iran lung Lung injury mustard mustard gas overexpression oxidative stress pathogenesis of SARS-CoV-2 pathologic Pulmonary infection receptor SARS-CoV-2 similarity suggested sulfur survivor susceptibility susceptible veteran [DOI] 10.1017/dmp.2020.156 PMC 바로가기 [Article Type] Responder Tools